maternal cosmetics use during pregnancy and risks of adverse outcomes: a prospective cohort study
Explore the association between maternal personal cosmetic use and risk of adverse outcomes during pregnancy and explore potential doses
Response relationship, we conducted a prospective cohort study of 9710 pregnant women in Zhuzhou city and Xiangtan city, Hunan province from 2016 to 2017.
Information on pregnant women and their pregnancy outcomes was collected using a structured questionnaire. Odds ratios (OR)
And 95% confidence intervals (CI)
Calculated by binary or multiple logistic regression.
The study population includes 4652 people (47. 9%)cosmetics non-Users and 5058 (52. 1%)
Cosmetics users.
The use of cosmetics is related to an increased risk of less than gestational age (SGA)(aORu2009=u20091. 23, 95%CI 1. 04 to 1. 44)
Compared with cosmeticsusers.
Positive dose-
The response relationship between cosmetic usage frequency and SGA was observed, although edge associations were found at low usage frequency (
1-2 times a week; aORu2009=u20091. 18, 95%CI 0. 99 to 1. 40)
Moderate Frequency of use (
3-4 times a week; aORu2009=u20091. 23, 95%CI 0. 92 to 1. 64). High-
Frequency of use of cosmetics (
≥ 5 times a week)
Significantly related to the high risk of SGA (aORu2009=u20091. 83, 95%CI 1. 25 to 2. 69).
There was no significant association between the use of personal cosmetics and the risk of premature birth, low birth weight, giant or older pregnancy.
Current research suggests that the use of personal cosmetics increases the risk of SGA, but further research is needed to determine which cosmetics may lead to a high risk of SGA.
Cosmetics are the necessities of our daily life, mainly used by young women, including pregnant women. Recent cross-
Cosmetic products were also used by 60-80% of pregnant women, including facial cleanser, Day Cream, foundation, mascara, lipstick, eyeliner, eye shadow and cosmetics, according to segmented studiesup remover.
Cosmetics contain a variety of chemicals (e. g.
Phthal acid salts, para-acid salts, formaldehyde, dioxygen six-ring, Amino, to hydroquinone, phenol, organic solvent)
And heavy metals (e. g.
Pb, Hg, As, Cd, Cr, Sb, Ni)
, It is either the efficacy ingredient that is deliberately added to enhance the skin care effect of cosmetics, or it is introduced from raw materials, auxiliary materials or technical problems in the production process.
It is reported that the use of cosmetics is related to the increase in the number of personal contact with parab gold, neighboring benzene Ester and benzene ketone.
Since most cosmetics are used directly on the skin, these dangerous chemicals can enter the human skin directly through the skin barrier, thus entering the whole body blood circulation, this may harm women\'s fertility and reproductive health.
Some of these chemicals are associated with adverse pregnancy outcomes.
For example, a French case
The control study showed that pregnant women had prenatal exposure to phenol (2,4-
PCP and 2,5-dichlorophenol)
Inversely proportional to the male birth weight, two studies have shown that pregnancy exposure to neighboring benzene Ester is associated with premature birth or loss of pregnancy.
Previous studies have shown that pregnant women have occupational exposure to cosmetics (e. g.
Hairdresser and beautician)
Related to abortion, perinatal mortality, premature delivery, low birth weight and minor gestational age (SGA)
And other adverse pregnancy outcomes.
A retrospective cohort study conducted in New York State showed that licensed beauticians are prone to babies with low birth weight compared to licensed realtors. Two registry-
Based on research, it is shown that beauticians have a higher risk of SGA compared to other working women. A recent meta-
The analysis confirmed that beauticians had a higher risk of infertility, fetal death and premature birth than the general population.
However, these studies focus on the adverse pregnancy outcomes of occupational exposure to cosmetics, not personal exposure.
As far as we know, there is no study to report the relationship between maternal cosmetic use (
Personal use of cosmetics)
Risk of pregnancy and adverse pregnancy outcomes.
This large Chinese prospective cohort study aims to study these associations and potential doses
Response Relationship
Related adverse pregnancy outcomes include premature birth, low birth weight, giant, SGA, and gestational age (LGA).
Response relationship, we conducted a prospective cohort study of 9710 pregnant women in Zhuzhou city and Xiangtan city, Hunan province from 2016 to 2017.
Information on pregnant women and their pregnancy outcomes was collected using a structured questionnaire. Odds ratios (OR)
And 95% confidence intervals (CI)
Calculated by binary or multiple logistic regression.
The study population includes 4652 people (47. 9%)cosmetics non-Users and 5058 (52. 1%)
Cosmetics users.
The use of cosmetics is related to an increased risk of less than gestational age (SGA)(aORu2009=u20091. 23, 95%CI 1. 04 to 1. 44)
Compared with cosmeticsusers.
Positive dose-
The response relationship between cosmetic usage frequency and SGA was observed, although edge associations were found at low usage frequency (
1-2 times a week; aORu2009=u20091. 18, 95%CI 0. 99 to 1. 40)
Moderate Frequency of use (
3-4 times a week; aORu2009=u20091. 23, 95%CI 0. 92 to 1. 64). High-
Frequency of use of cosmetics (
≥ 5 times a week)
Significantly related to the high risk of SGA (aORu2009=u20091. 83, 95%CI 1. 25 to 2. 69).
There was no significant association between the use of personal cosmetics and the risk of premature birth, low birth weight, giant or older pregnancy.
Current research suggests that the use of personal cosmetics increases the risk of SGA, but further research is needed to determine which cosmetics may lead to a high risk of SGA.
Cosmetics are the necessities of our daily life, mainly used by young women, including pregnant women. Recent cross-
Cosmetic products were also used by 60-80% of pregnant women, including facial cleanser, Day Cream, foundation, mascara, lipstick, eyeliner, eye shadow and cosmetics, according to segmented studiesup remover.
Cosmetics contain a variety of chemicals (e. g.
Phthal acid salts, para-acid salts, formaldehyde, dioxygen six-ring, Amino, to hydroquinone, phenol, organic solvent)
And heavy metals (e. g.
Pb, Hg, As, Cd, Cr, Sb, Ni)
, It is either the efficacy ingredient that is deliberately added to enhance the skin care effect of cosmetics, or it is introduced from raw materials, auxiliary materials or technical problems in the production process.
It is reported that the use of cosmetics is related to the increase in the number of personal contact with parab gold, neighboring benzene Ester and benzene ketone.
Since most cosmetics are used directly on the skin, these dangerous chemicals can enter the human skin directly through the skin barrier, thus entering the whole body blood circulation, this may harm women\'s fertility and reproductive health.
Some of these chemicals are associated with adverse pregnancy outcomes.
For example, a French case
The control study showed that pregnant women had prenatal exposure to phenol (2,4-
PCP and 2,5-dichlorophenol)
Inversely proportional to the male birth weight, two studies have shown that pregnancy exposure to neighboring benzene Ester is associated with premature birth or loss of pregnancy.
Previous studies have shown that pregnant women have occupational exposure to cosmetics (e. g.
Hairdresser and beautician)
Related to abortion, perinatal mortality, premature delivery, low birth weight and minor gestational age (SGA)
And other adverse pregnancy outcomes.
A retrospective cohort study conducted in New York State showed that licensed beauticians are prone to babies with low birth weight compared to licensed realtors. Two registry-
Based on research, it is shown that beauticians have a higher risk of SGA compared to other working women. A recent meta-
The analysis confirmed that beauticians had a higher risk of infertility, fetal death and premature birth than the general population.
However, these studies focus on the adverse pregnancy outcomes of occupational exposure to cosmetics, not personal exposure.
As far as we know, there is no study to report the relationship between maternal cosmetic use (
Personal use of cosmetics)
Risk of pregnancy and adverse pregnancy outcomes.
This large Chinese prospective cohort study aims to study these associations and potential doses
Response Relationship
Related adverse pregnancy outcomes include premature birth, low birth weight, giant, SGA, and gestational age (LGA).
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